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Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE).1 As previously described, LN occurs more frequently in Hispanic and African-American people in the multiethnic US LUMINA (Lupus in Minorities: Nature vs Nurture) cohort.2 With more patients (one-third) and years of observation (2949.3 patient-years from enrolment or baseline), we have now examined whether LN occurs earlier in the disease course in these patients relative to Caucasians. Four hundred and forty-nine patients (American College of Rheumatology (ACR) criteria, age ≥16 years, disease duration ≤5 years, predominantly women) were studied. Time-to-LN (ACR criterion (persistent proteinuria >0.5 g/day or ≥3 if quantitation not performed or cellular casts)) from baseline (incident cases) was examined by multivariable Cox proportional hazards regression adjusting for pertinent …
Funding Supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Disease P01 AR49084, General Clinical Research Centers M01-RR02558 (UTH) and M01-RR00032 (UAB) and from the National Center for Research Resources (NCRR/HIH) RCMI Clinical Research Infrastructure Initiative (RCRII) 1P20RR11126 (UPR). The work of PIB was also supported by Programa de Postgrado Becas Chile.
Competing interests None.
Ethics approval The Institutional Review Board of the study centres approved the study. Written informed consent was obtained from each subject according to the Declaration of Helsinki.
Provenance and peer review Not commissioned; externally peer reviewed.
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