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The objective of this short communication is to demonstrate the feasibility and effectiveness of multiple placebos to individualise treatment when using classical Ayurveda for rheumatoid arthritis in well controlled, double-blind, placebo-controlled trials.
A total of 46 patients ≥18 years of age, with active rheumatoid arthritis as diagnosed using American College of Rheumatology criteria, were randomised to 1 of 3 outpatient treatment groups: methotrexate+placebo Ayurveda; Ayurveda+placebo methotrexate; and methotrexate+Ayurveda. The Ayurvedic doctor was free to choose from 148 formulations, which were in the form of 6 traditional dosage forms: decoctions, herbal powders, pills, herbal wines, herbal jams and herb-infused oils. Six placebos were also formulated, with each placebo representing a dosage form.
All appropriate institutional review board approvals were obtained. Formulations were …
Funding This study was supported by an award from the National Center for Complementary and Alternative Medicine, NIH grant 1 R21 AT-01969 and by the Ayurvedic Trust, Coimbatore, India.
Competing interests None.
Patient consent Obtained.
Ethics approval This study was conducted with the approval of the UCLA.
Provenance and peer review Not commissioned; externally peer reviewed.