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Serum β2 microglobulin correlates with the new ESSDAI in patients with Sjögren's syndrome
  1. Marja Pertovaara1,2,
  2. Markku Korpela1,2
  1. 1Department of Internal Medicine, Centre for Rheumatic Diseases, Tampere University Hospital, Tampere, Finland
  2. 2Department of Internal Medicine, University of Tampere, Medical School, Tampere, Finland
  1. Correspondence to Marja Pertovaara, Department of Internal Medicine, Centre for Rheumatic Diseases, Tampere University Hospital, PO Box 2000, FIN-33521 Tampere, Finland; marja.pertovaara{at}

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Primary Sjögren's syndrome (pSS) is characterised clinically by sicca symptoms of the eyes and mouth. However, a proportion of pSS patients also present with extraglandular symptoms, for which immunosuppressive treatments may be needed. An expert panel of the European League Against Rheumatism (EULAR) has very recently developed a EULAR Sjögren's syndrome disease activity index (ESSDAI) to evaluate these systemic symptoms of pSS.1 The index consists of 12 organ-specific domains, which are predominantly clinical; only 2 of them include haematological (cytopenias) or biological (clonal component, serum complement levels, serum IgG and cryoglobulins) findings.1

β2 Microglobulin is a low-molecular weight (11.8 kDa) polypeptide protein, which is one of the major histocompatibility class I molecules on the cell surfaces of all nucleated cells and is produced in particular by lymphocytes. We have previously reported that serum β …

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  • Funding This study was financially supported by the Competitive Research Funding of Tampere University Hospital, Tampere, Finland, and the Tampere Tuberculosis Foundation.

  • Ethics approval The study has been approved by the Ethical Committee of Tampere University Hospital, Tampere, Finland.

  • Provenance and peer review Not commissioned; externally peer reviewed.