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The impact of knee and hip chondrocalcinosis on disability in older people: the ProVA Study from northeastern Italy
  1. Estella Musacchio1,
  2. Roberta Ramonda2,
  3. Egle Perissinotto3,
  4. Leonardo Sartori1,
  5. Rosemarie Hirsch4,
  6. Leonardo Punzi2,
  7. Sabina Zambon1,
  8. Maria Chiara Corti5,
  9. Giovannella Baggio6,
  10. Enzo Manzato7,8,
  11. Andrea Doria2,
  12. Gaetano Crepaldi8
  1. 1Clinica Medica I, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
  2. 2Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
  3. 3Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy
  4. 4Center for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, Maryland, USA
  5. 5Azienda ULSS N 16, Padova, Italy
  6. 6Clinica Geriatrica, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
  7. 7Medicina Generale, Azienda Ospedaliera, University of Padova, Padova, Italy
  8. 8Istituto di Neuroscienze, Aging Branch-National Council for Research, CNR, Padova, Italy
  1. Correspondence to Dr Roberta Ramonda, Rheumatology Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliera, University of Padova, Via Giustiniani 2, 35128 Padova, Italy; roberta.ramonda{at}


Objectives Chondrocalcinosis is frequently associated with osteoarthritis. The role of osteoarthritis in the onset and progression of disability is well known. The impact of chondrocalcinosis on disability has never been investigated in epidemiological studies.

Methods Progetto Veneto Anziani is a survey of 3099 older Italians, focusing on chronic diseases and disability. Assessment was by questionnaires, physical performance tests and clinical evaluations. Chondrocalcinosis was determined by x-ray readings of 1629 consecutive subjects. Knee and hip osteoarthritis severity was evaluated by summing the radiographic features score (RFS) assigned during x-ray reading.

Results Subjects with chondrocalcinosis were older and more frequently women (age-adjusted p<0.0001). The gender association disappeared following adjustment for osteoarthritis severity. However, at the knee, the prevalence of osteoarthritis was higher in chondrocalcinosis patients independently of age and sex (age-adjusted p<0.0001). No difference was found between chondrocalcinosis and controls in sociodemographic variables and comorbidity. Knee chondrocalcinosis was strongly associated with clinical features of knee osteoarthritis and with disability assessment parameters in the bivariate analysis. Most associations remained after adjusting for age. After further adjustment for RFS, a significant association remained for knee deformity and pain, the need for a cane, difficulty walking 500 m, using a toilet, shopping and repeatedly rising from a chair.

Conclusions Pain and physical function are the outcome measures of choice for assessing disability in osteoarthritis patients. The presence of chondrocalcinosis contributes to both, independently of age and osteoarthritis severity, thus compromising the quality of life and worsening comorbidity.

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  • The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

  • Funding The ProVA Study was supported by the Fondazione Cassa di Risparmio di Padova e Rovigo.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the local ethics committees at the study centres.

  • Provenance and peer review Not commissioned; externally peer reviewed.