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Correlation of serum level of high mobility group box 1 with the burden of granulomatous inflammation in granulomatosis with polyangiitis (Wegener's)
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  • Published on:
    HMGB-1 in ANCA-associated vasculitis (AAV):correlation with disease manifestations
    • Annette Bruchfeld, MD, Associate Professor
    • Other Contributors:
      • Marten Wendt, Johan Bratt, Abdul R Qureshi, Sangeeta Chavan, Kevin J Tracey, Iva Gunnarsson

    Dear editor,

    Recently Henes et al reported that serum levels of the proinflammatory mediator high mobility group box-1 protein (HMGB1) were elevated and showed a significant correlation with the burden of granulomatous inflammation in patients with Granulomatosis with polyangiitis (GPA or Wegener) (1). The same group has previously published data suggesting that HMGB1 is a marker of GPA and that HMGB1 is not detec...

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