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Single-nucleotide polymorphisms (SNPs) of the human interferon γ gene (IFNG) were found to be associated with susceptibility to systemic lupus erythematosus (SLE) in our recent case–control study on 1759 unrelated Korean participants (742 SLE patients and 1017 controls).1 In particular, the SLE-susceptible (minor) allele in an SNP (rs2430561) located on an NF-κB binding site in the first intron was associated with elevated IFNG expression,2,–,4 consistent with previous functional implications of high expression levels of IFNG in lupus pathogenesis in human disease and murine models,5,–,7 although this SNP showed no association in several previous small studies.8,–,10
In our original study,1 the effect size of this SNP was considerable with an OR of …
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