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Funding This study has been supported by grants from the University of Florence (Progetti di Ricerca di Ateneo, ex 60% to L. Ibba-Manneschi and M. Matucci-Cerinic).
Competing interests None.
Patient consent Obtained.
Ethics approval The study was approved by the Institutional Review Board. All subjects gave written informed consent.
Provenance and peer review Not commissioned; externally peer reviewed.
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