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Extended report
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
  1. Fabienne Niederer1,
  2. Caroline Ospelt1,2,
  3. Fabia Brentano1,
  4. Michael O Hottiger3,
  5. Renate E Gay1,4,
  6. Steffen Gay1,4,
  7. Michael Detmar5,
  8. Diego Kyburz1,4
  1. 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
  2. 2Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  3. 3Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
  4. 4Zurich Center of Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland
  5. 5Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
  1. Correspondence to Diego Kyburz, Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland; diego.kyburz{at}usz.ch

Footnotes

  • Funding This work was supported by the Swiss National Fund grant 32 -120702 (to DK), by FP7 Masterswitch and IAR Epalinges (to CO, REG, SG).

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the ethics committee of the canton of Zurich.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Funding This work was supported by the Swiss National Fund grant 32 -120702 (to DK), by FP7 Masterswitch and IAR Epalinges (to CO, REG, SG).

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the ethics committee of the canton of Zurich.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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