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A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells
  1. Michele Bombardieri1,
  2. Ngar-Woon Kam1,
  3. Fabia Brentano2,
  4. Ken Choi1,
  5. Andrew Filer3,
  6. Diego Kyburz2,
  7. Iain B McInnes4,
  8. Steffen Gay2,
  9. Christopher Buckley3,
  10. Costantino Pitzalis1
  1. 1Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK
  2. 2Centre for Experimental Rheumatology, University Hospital, Zürich, Switzerland
  3. 3Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, Institute for Biomedical Research, The University of Birmingham, Birmingham, UK
  4. 4Centre for Rheumatic Diseases, Division of Immunology, Infection and Inflammation, Glasgow Royal Infirmary, University of Glasgow, Glasgow, UK
  1. Correspondence to Dr Michele Bombardieri, Centre for Experimental Medicine and Rheumatology, 2nd Floor, John Vane Science Centre, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK; m.bombardieri{at}qmul.ac.uk

Footnotes

  • MB and NWK contributed equally to this work.

  • Funding Arthritis Research UK.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the East London & The City Research Ethics Committee 3 (LREC07/Q0605/29).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • MB and NWK contributed equally to this work.

  • Funding Arthritis Research UK.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the East London & The City Research Ethics Committee 3 (LREC07/Q0605/29).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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