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Autoimmune diseases such as rheumatoid arthritis are characterised by persistently activated CD4 T cells which circulate from the synovial tissues into the lymph nodes where they encounter multiple contacts with bystander cells including resting CD4 T cells. The authors have recently shown that activated T cells induce the proliferation and production of cytokines with immunoregulatory potential from resting CD4 T cells by homotypic T cell interaction. Since the compromised function of regulatory T cells …
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