Article Text
T cells
Identification of citrullinated vimentin peptides as T cell epitopes in HLA-DR4 positive RA patients
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Objective
Antibodies directed against citrullinated proteins (ACPA) are highly specific for rheumatoid arthritis (RA). The production of ACPA is most likely dependent on the presence of T cells as ACPA have undergone isotype switching and associate with the shared epitope-containing HLA-DRB1 alleles (SE). Vimentin is a likely candidate protein …