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The pathological mechanisms leading to a lost of immunological tolerance and inciting rheumatoid arthritis (RA) are not fully understood. However, autoimmunity towards several post-translationally modified (citrullinated) synovial antigens is thought to have a central role in disease pathogenesis. Of particular interest is vimentin, a synovial antigen to which antibodies towards its citrullinated form are commonly found in both RA sera and synovial fluid. …
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