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Identification and function of T cells reactive with citrullinated vimentin in HLA-DRB1*0401 humanised mice and rheumatoid arthritis patients
  1. O Snir,
  2. M Rieck,
  3. K Klich,
  4. L Klareskog,
  5. J H Buckner,
  6. V Malmström
  1. Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institute, Solna, Stockholm, Sweden

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Background

The pathological mechanisms leading to a lost of immunological tolerance and inciting rheumatoid arthritis (RA) are not fully understood. However, autoimmunity towards several post-translationally modified (citrullinated) synovial antigens is thought to have a central role in disease pathogenesis. Of particular interest is vimentin, a synovial antigen to which antibodies towards its citrullinated form are commonly found in both RA sera and synovial fluid. …

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