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Constitutive co-stimulation by B cells is sufficient to trigger T cell-driven autoimmune disease
  1. G Franco Salinas,
  2. T Cantaert,
  3. M Nolte,
  4. E Bettelli,
  5. V K Kuchroo,
  6. P P Tak,
  7. R A Van Lier,
  8. D L Baeten
  1. Clinical Immunology and Rheumatology, Academical Medical Centrum, Netherlands

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Objective

At least two distinct signals are required for classical T cell activation: (1) the cognate antigen presented in the context of MHC class II molecules and (2) co-stimulation. Using myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) as a prototypical model of T cell-driven autoimmune disease, the authors and others demonstrated previously that autoimmune B cells are crucial in T cell activation by acting as potent antigen-presenting cells. Although the importance of …

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