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Mesenchymal stem cells participate in the loop leading to amplification of inflammation through secretion of interleukin (IL)6, IL1β and IL8
  1. A Eljaafari,
  2. M-L Tartelin,
  3. P Miossec
  1. Immunogenomics Unit, EA 4130, Hospices Civils de Lyon, France

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Background

Mesenchymal cells and subsets of T cells interact in the rheumatoid arthritis (RA) synovium leading to the local production of inflammatory cytokines. These high levels suggest a defect in the regulation of cytokine secretion, but the respective contribution of Th1 and Th17 cells remains to be clarified.

Objectives

Mesenchymal stem cells (MSC) are known to play a role in the regulation of the immune response and are present …

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