Article Text
T cells
Molecular mechanisms of peripheral CD25 regulatory T cell (Treg) development
Statistics from Altmetric.com
Compromised development and/or function of CD25 regulatory T cells (Tregs) is of central importance for the development of autoimmune diseases. The mechanisms that regulate the generation of peripheral Tregs are, however, largely unknown. To gain insights into Treg differentiation on a molecular level, the authors investigated gene expression profiles of Tregs at different developmental stages.
Human Tregs were generated in vitro from CD4 CD25-naive T cells in …