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T cells
MicroRNA-182 promotes clonal expansion of activated T helper cells
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  1. A-B Stittrich,
  2. C Haftmann,
  3. A Hegazy,
  4. M Floessdorf,
  5. J Dong,
  6. F Fuhrmann,
  7. G Heinz,
  8. N Li,
  9. Z Fang,
  10. A Jahn,
  11. R Baumgrass,
  12. J Grün,
  13. W Chen,
  14. T Höfer,
  15. M Löhning,
  16. H-D Chang,
  17. N Rajewsky,
  18. A Radbruch,
  19. M-F Mashreghi
  1. Deutsches Rheuma Forschungszentrum, Germany

https://doi.org/10.1136/ard.2010.129668a

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    Upon activation by antigen, T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the forkhead transcription factor Foxo1, which suppresses proliferation in resting T helper lymphocytes. In the initial antigen-dependent phase of clonal expansion, Foxo1 is inactivated by antigen receptor-dependent post-translational modifications. …

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