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Thyroid disease and vitamin D deficiency
  1. S Kivity,
  2. N Agmon-Levin,
  3. M Zisappl,
  4. Y Shapira,
  5. V Barak,
  6. K Dankó,
  7. Z Szekanecz,
  8. M Szyper-Kravitz,
  9. P langevitz,
  10. B Gilburd,
  11. Y Shoenfeld
  1. Center for Autoimmune Diseases, Department of Medicine ‘A & C’, Sheba Medical Center, Tel-Hashomer, Israel

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The role of vitamin D as an immune-modulator has been emphasised in recent years, and low levels of this hormone were observed in several autoimmune diseases.1 Vitamin D mediates its effect through binding to vitamin D receptor (VDR) and activation of VDR-responsive genes. VDR-gene polymorphism was found to associate with autoimmune thyroid diseases (AITD), however studies exploring levels of vitamin D in patients with AITD are scarce and yield conflicting results. We therefore evaluated the levels of vitamin D in patients with AITD compared with non-autoimmune thyroid disease and healthy subjects.


Serum vitamin D levels were measured in 50 patients with AITDs, 42 patients with non-autoimmune thyroid diseases and 98 healthy subjects using the Liaison chemiluminescent immunoassays (DiaSorin, Italy). Vitamin D deficiency was designated at <10 ng/ml. Patients were evaluated for anti-thyroid antibodies, thyroid function and demographic parameters.


The prevalence of vitamin D deficiency was significantly higher in patients with AITD compared with healthy individuals (72% vs 30.6%; p<0.001), and in patients with Hashimoto's thyroiditis compared with patients with non-AITD (79% vs 52%; p<0.05). Vitamin D deficiency significantly correlated with the presence of anti-thyroid antibodies (p=01) and a trend towards an association with disturbed thyroid function was also observed (p=0.59).


Significantly low levels of vitamin D were documented in patients with AITD, and were related to the presence of anti-thyroid antibodies and disturbed thyroid function. Although further studies are required, the role of vitamin D in the pathogenesis of autoimmune thyroid diseases is suggested and supplementation should be considered.