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Lymphotoxin α stimulates proliferation and proinflammatory cytokine secretion of rheumatoid arthritis fibroblast-like synoviocytes
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  1. F Calmon Hamaty,
  2. M Hahne,
  3. B Combe,
  4. J Morel
  1. Institut de Génétique Moléculaire de Montpellier, France

https://doi.org/10.1136/ard.2010.129650e

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    Background and Purpose

    Lymphotoxin α (LTα) is a proinflammatory cytokine with structural homology with tumour necrosis factor α (TNFα). Both cytokines bind to the receptors TNFRI and TNFRII, and LTα also binds to the herpes virus entry mediator (HVEM). Increased LTα levels have been detected in patients with rheumatoid arthritis (RA), but its role in RA is poorly characterised. To elucidate its role in comparison with …

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