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Production and biological role of hepatocyte and myeloid cell-derived interleukin-1 receptor antagonist in a model of systemic inflammation
  1. C Lamacchia,
  2. G Palmer,
  3. E Rodriguez,
  4. D Talabot-Ayer,
  5. C Gabay
  1. Division of Rheumatology and Department of Pathology and Immunology, University of Geneva School of Medicine (CMU), Geneva, Switzerland

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Background

Interleukin-1 receptor antagonist (IL1Ra) is a specific IL1 inhibitor that possesses anti-inflammatory activities in experimental models and in patients. Interestingly, administration of IL1Ra, particularly in animal models, can ameliorate the physiological consequences of septic shock. The contribution of the IL1/IL1Ra balance during endotoxaemia was confirmed by the high susceptibility of IL1Ra deficient mice to a lethal dose of lipopolysaccharide (LPS). Previous in vitro data demonstrated that both hepatocytes and myeloid cells produce IL1Ra in large amounts in response to LPS. …

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