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Interleukin-1 receptor antagonist (IL1Ra) is a specific IL1 inhibitor that possesses anti-inflammatory activities in experimental models and in patients. Interestingly, administration of IL1Ra, particularly in animal models, can ameliorate the physiological consequences of septic shock. The contribution of the IL1/IL1Ra balance during endotoxaemia was confirmed by the high susceptibility of IL1Ra deficient mice to a lethal dose of lipopolysaccharide (LPS). Previous in vitro data demonstrated that both hepatocytes and myeloid cells produce IL1Ra in large amounts in response to LPS. …
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