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Decreased soluble tumour necrosis factor expression in spondylarthritis versus rheumatoid arthritis synovitis
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  1. N Yeremenko,
  2. C Ambarus,
  3. H Masdar,
  4. P P Tak,
  5. D L Baeten
  1. Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands

https://doi.org/10.1136/ard.2010.129643w

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    Tumour necrosis factor (TNF) α is a pivotal mediator of synovial tissue inflammation in rheumatoid arthritis (RA) as well as in spondyloarthritis (SpA), as evidenced by the therapeutic effects of TNF blockade in both diseases. However, the levels of soluble TNF (sTNF) are strongly reduced in SpA versus RA synovial fluid (SF). Therefore we aimed to unravel the potential differences in TNF signalling between SpA and RA.

    Synovial biopsies and SF were obtained from actively inflamed knee joints of RA and SpA patients. Soluble mediators in SF were analysed by ELISA. Synovial tissue expression …

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