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Effect of immunosuppressive treatment on interleukin 15 in muscle tissue of patients
  1. M Zong1,
  2. I Loell1,
  3. E Lindroos1,
  4. G Nader1,
  5. I B Mclnnes2,
  6. I E Lundberg1
  1. 1Department of Medicine, Rheumatology Unit, Karolinska Institutet/Karolinska University Hospital, Solna, Stockholm, Sweden
  2. 2Centre for Rheumatic Diseases, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK

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Background

Polymyositis and dermatomyositis are chronic inflammatory diseases of primary affecting skeletal muscle where the infiltrates are composed of T cells and where CD8 T cells are often found. The molecular mechanisms that promote T cell proliferation and cause muscle weakness are still unknown. In this context, interleukin (IL)15 is of potential interest as this cytokine could induce proliferation of CD8 T cells and could have a role in muscle fibre regeneration.

Objectives

To investigate the expression of IL15 and IL15 receptor α (IL15Rα) in muscle biopsies from patients …

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