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Polymyositis and dermatomyositis are chronic inflammatory diseases of primary affecting skeletal muscle where the infiltrates are composed of T cells and where CD8 T cells are often found. The molecular mechanisms that promote T cell proliferation and cause muscle weakness are still unknown. In this context, interleukin (IL)15 is of potential interest as this cytokine could induce proliferation of CD8 T cells and could have a role in muscle fibre regeneration.
To investigate the expression of IL15 and IL15 receptor α (IL15Rα) in muscle biopsies from patients …
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