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We have previously reported that anti-CII-containing immune complexes (anti-CII IC) induced production of tumour necrosis factor (TNF) β, interleukin (IL)1α and IL8 from monocytes via FcγRIIa.1 We have also shown that high levels of anti-CII were associated with IC-induced production of pro-inflammatory cytokines in vitro and increased laboratory signs of inflammation 2 and increased radiological erosions at the time of diagnosis. 3 The objective of this study was to establish an in vitro …
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