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Anti-type II collagen-immune complex-induced production of interleukin 1β and tumour necrosis factor α stimulate production of matrix metalloproteinases from monocyte/rheumatoid arthritis synovial fibroblast co-cultures
  1. M Mullazehi,
  2. L Mathsson,
  3. O Feldt,
  4. K Schubert,
  5. M Korotkova,
  6. V Malmström,
  7. J Rönnelid
  1. Uppsala University, Uppsala, Sweden

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We have previously reported that anti-CII-containing immune complexes (anti-CII IC) induced production of tumour necrosis factor (TNF) β, interleukin (IL)1α and IL8 from monocytes via FcγRIIa.1 We have also shown that high levels of anti-CII were associated with IC-induced production of pro-inflammatory cytokines in vitro and increased laboratory signs of inflammation 2 and increased radiological erosions at the time of diagnosis. 3 The objective of this study was to establish an in vitro …

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