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Systemic sclerosis as prototypic disease with high levels of functional antibodies against angiotensin II type-1 and endothelin-1 type A receptor strongly predicting prognosis
  1. G Riemekasten,
  2. A Philippe,
  3. I Lukitsch,
  4. T Slowinski,
  5. M Näther
  1. Charité Universitätsmedizin Berlin, Germany

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Background

Systemic sclerosis (SSc) features autoimmunity, vasculopathy and tissue fibrosis; the renin-angiotensin and endothelin systems have been implicated. The authors hypothesised a role for autoimmune receptor stimulation.

Methods

The authors tested sera of 478 SSc patients (298 in the study cohort and 180 from two independent cohorts), 372 …

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