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  • Systemic sclerosis as prototypic disease with high levels of functional antibodies against angiotensin II type-1 and endothelin-1 type A receptor strongly predicting prognosis

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Autoantibodies
Systemic sclerosis as prototypic disease with high levels of functional antibodies against angiotensin II type-1 and endothelin-1 type A receptor strongly predicting prognosis
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  1. G Riemekasten,
  2. A Philippe,
  3. I Lukitsch,
  4. T Slowinski,
  5. M Näther
  1. Charité Universitätsmedizin Berlin, Germany

https://doi.org/10.1136/ard.2010.129577k

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    Background

    Systemic sclerosis (SSc) features autoimmunity, vasculopathy and tissue fibrosis; the renin-angiotensin and endothelin systems have been implicated. The authors hypothesised a role for autoimmune receptor stimulation.

    Methods

    The authors tested sera of 478 SSc patients (298 in the study cohort and 180 from two independent cohorts), 372 …

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