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We are currently developing local gene therapy for the treatment of rheumatoid arthritis (RA) using interferon β (IFNβ) as therapeutic gene and rAAV5 as vector. We generated a rAAV5 vector that expresses hIFNβ under control of an inflammation inducible promoter (rAAV5.NFkB.hIFNβ). To support development of our clinical gene therapy programme a robust assay is needed to transduce different cell lines with rAAV5.NFkB.hIFNβ. In vitro, rAAV5 does not transduce cells efficiently, including fibroblast-like synoviocytes (FLS), the main target cell …
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