Article Text
Innate immunity
Mast cells contribute to synovial inflammation in non-psoriatic and psoriatic spondyloarthritis
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Objective
The authors recently observed a striking synovial infiltration with cells positive for C-kit, a marker for mast cells, in psoriatic arthritis (PsA). As mast cells have potent inflammatory functions including the production of tumour necrosis factor (TNF), the authors performed a systematic analysis of C-kit positive cells in different forms of chronic inflammatory arthritis.
Materials and Methods
Synovial tissue biopsies from active rheumatoid arthritis (RA), non-psoriatic spondyloarthritis (SpA) and PsA were stained by …