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Innate immunity
Alarmin S100A8 causes severe cartilage damage in antigen-induced arthritis through TLR4 activation and upregulation of FcεRI and FcεRIV
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  1. P L E M van Lent1,
  2. L Grevers1,
  3. R Schelbergen1,
  4. A Blom1,
  5. A Sloetjes1,
  6. T Vogl2,
  7. J Roth2,
  8. W B van den Berg1
  1. 1Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  2. 2Department of Dermatology, UKM, Munster, Germany

https://doi.org/10.1136/ard.2010.129627o

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    The ‘alarmins’ S100 A8 and A9 have been described not only as markers for inflammation but may also be involved in induction of erosive cartilage destruction.1 S100A8 represents the active form whereas S100A9 binds to S100A8, protecting the protein from degradation. The aim of the study is to identify the mechanisms of S100 involvement in severe cartilage destruction during antigen-induced arthritis.

    Antigen-induced arthritis (AIA) was induced in knee joints of S100A8/A9-/- mice (myeloid cells also …

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