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Innate immunity
Alarmin interleukin 33 is overexpressed in psoriasis and induces ST2-dependent psoriasis-like dermatitis
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  1. A J Hueber,
  2. A M Miller,
  3. D L Asquith,
  4. N L Millar,
  5. D Gilchrist,
  6. A Gracie,
  7. I B McInnes
  1. University of Glasgow, UK
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http://dx.doi.org/10.1136/ard.2010.129627n

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    Psoriasis is an inflammatory skin disease characterised by hyperproliferation of keratinocytes, infiltration of inflammatory cells, impaired barrier function and alteration of tight junction proteins.

    The interleukin 1 (IL1) family member IL33 has recently been described as an alarmin expressed in epithelial cells at body barriers, …

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