Article Text
Innate immunity
Heterogeneous nuclear ribonucleoproteinassociated nucleic acids trigger disease in a rat transfer model of arthritis
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Toll-like receptor (TLR)-mediated autoimmunity to nucleic acid-protein complexes has been implicated in the pathogenesis of systemic lupus erythematosus, whereas information regarding the influence of nucleic acid sensing TLRs on the development of rheumatoid arthritis (RA) is scarce. The authors have recently shown that the nucleic acid-binding autoantigen heterogeneous nuclear ribonucleoprotein (hnRNP)-A2 is not …