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Antibodies against citrullinated proteins (ACPA) have been reported in the order of 70% of all cases with rheumatoid arthritis (RA). The authors and other groups have also shown that approximately one third of the ACPA-positive RA-cases carry antibodies against the calcium-dependent thiol-enzyme which catalyses citrullination, namely peptidylarginine deiminase (PAD). These patients seem to suffer from a more severe form of RA. The presence of two distinct subsets of RA based on presence or …
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