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Cellular factor XIII and peptidylarginine deiminase-catalysed citrullination in rheumatoid arthritis
  1. B Roth,
  2. F Wollheim,
  3. P Stenberg
  1. RA, Department of Clinical Sciences, Lund University, Malmö, Sweden

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Introduction

Antibodies against citrullinated proteins (ACPA) have been reported in the order of 70% of all cases with rheumatoid arthritis (RA). The authors and other groups have also shown that approximately one third of the ACPA-positive RA-cases carry antibodies against the calcium-dependent thiol-enzyme which catalyses citrullination, namely peptidylarginine deiminase (PAD). These patients seem to suffer from a more severe form of RA. The presence of two distinct subsets of RA based on presence or …

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