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JKTBP (hnRNPDL) is a novel toll7/9 dependent target in humans and animal models of inflammatory rheumatic diseases
  1. B Marklein1,
  2. Z Konthur2,
  3. A Cope3,
  4. M Shlomchik4,
  5. G Burmester1,
  6. K Skriner1
  1. 1Department of Rheumatology and Clinical Immunology, Humboldt University and Free University, Germany
  2. 2Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany
  3. 3Department of Rheumatology, King's College School of Medicine, London, UK
  4. 4Yale School of Medicine, New Haven, Connecticut, USA

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Autoimmune diseases are characterised and regularly diagnosed by the presence of autoantibodies to heterogeneous nuclear RNP (hnRNP) autoantigens. These proteins represent a group of autoantigens which are targeted by autoantibodies from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and mixed connective tissue disease. The authors investigated a new member of the hnRNP family targeted by autoantibodies and tested a combination of hnRNPs in humans and …

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