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Rheumatoid arthritis (RA) patients have variable but comparable NLRP3-inflammasome induction to controls
  1. C Choulaki,
  2. E Petraki,
  3. E Choustoulaki,
  4. G Goulielmos,
  5. D Boumpas,
  6. P Sidiropoulos
  1. University of Crete, Greece

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Background and Objective

Data from animal models support an important role for interleukin 1b (IL1b) in the pathogenesis of rheumatoid arthritis (RA).1,2 NLRP3-inflammasome is one of the main cellular platforms for IL1b production upon activation by external or self danger signals.3 The authors The authors inflammasome in peripheral blood of patients with RA.

Methods

Heparin-anticoagulated whole blood from patients and healthy controls (HC) was used after red blood cell lysis. Monocytes were immunomagnetically isolated from peripheral blood mononuclear cells. TLR4 …

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