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  • Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon α activity in patients with systemic lupus erythematosus

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Genetics and gene regulation
Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon α activity in patients with systemic lupus erythematosus
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  1. R Salloum,
  2. B S Franek,
  3. S N Kariuki,
  4. L Rhee,
  5. R A Mikolaitis,
  6. M Jolly,
  7. T O Utset,
  8. T B Niewold
  1. University of Chicago, USA

https://doi.org/10.1136/ard.2010.129619n

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    Objective

    Interferon α (IFNγ) is a heritable risk factor for systemic lupus erythematosus (SLE). Genetic variation near IFN regulatory factor 7 (IRF7) is implicated in SLE susceptibility. SLE-associated autoantibodies can stimulate IFNγ production through the Toll-like receptor/IRF7 pathway. The authors hypothesised that variants of IRF7 may cause risk of SLE by increasing IFNγ production, …

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