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Genetic variation in promoter sequence of B cell-activating factor gene is associated with increased risk of myositis development
  1. M Faustova,
  2. P Novota,
  3. O Krystufkova,
  4. H Hulejova,
  5. J Vencovsky
  1. Department of Molecular Biology and Immunogenetics, Institute of Rheumatology, Prague, Czech Republic

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Introduction

The protein encoded by B cell-activating factor (BAFF) gene is a member of the tumour necrosis factor (ligand) superfamily. This protein is expressed by myeloid line cells (dendritic cells, macrophages, monocytes), partly by T cells and is secreted mostly by dendritic cells. It increases the survival of B cells in vitro and regulates peripheral B cells. It also seems to play a role in T cell activation providing a co-stimulatory signal. The promoter region of BAFF gene contains …

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