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Upregulated SUMO-2/3 expression is involved in the regulation of apoptosis and matrix metalloproteinase expression in rheumatoid arthritis synovial fibroblasts
  1. S Frank,
  2. S Strietholt,
  3. C Wunrau,
  4. T Pap,
  5. M A Peters
  1. Institute of Experimental Musculoskeletal Medicine, University of Muenster, Germany

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SUMO-2/3 belongs to the small ubiquitin-related modifier family of proteins that have been implicated in many biological functions such as intracellular protein transport, control of gene expression and stability of proteins. The authors have previously shown that elevated expression of SUMO-1 in rheumatoid arthritis (RA) synovial fibroblasts (RASF) confers the resistance against Fas-induced apoptosis through SUMO-1/SENP1-dependent mechanisms. Based on these findings, the authors set out to analyse the expression of SUMO-2/3 in human RA and in a tumour necrosis …

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