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Angiogenesis contributes to inflammation and joint destruction in rheumatoid arthritis (RA). Angiopoietins 1 (Ang-1) and Ang-2, which mediate blood vessel remodelling, as well as their receptor Tie2, are expressed in inflamed synovial tissue. The authors have recently shown that Ang-1 expression relative to Ang-2 is significantly higher in RA compared to psoriatic arthritis, corresponding with enhanced activation …
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