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The Ang-1/Tie2 angiogenic axis is selectively engaged in rheumatoid arthritis (RA) synovial tissue even before ACR criteria of RA are met
  1. M G H van de Sande,
  2. D de Launay,
  3. S Krausz,
  4. G P M van de Sande,
  5. C A Wijbrandts,
  6. P P Tak,
  7. K A Reedquist
  1. Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands

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Angiogenesis contributes to inflammation and joint destruction in rheumatoid arthritis (RA). Angiopoietins 1 (Ang-1) and Ang-2, which mediate blood vessel remodelling, as well as their receptor Tie2, are expressed in inflamed synovial tissue. The authors have recently shown that Ang-1 expression relative to Ang-2 is significantly higher in RA compared to psoriatic arthritis, corresponding with enhanced activation …

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