Article Text

Download PDFPDF

The Ang-1/Tie2 angiogenic axis is selectively engaged in rheumatoid arthritis (RA) synovial tissue even before ACR criteria of RA are met
Free
  1. M G H van de Sande,
  2. D de Launay,
  3. S Krausz,
  4. G P M van de Sande,
  5. C A Wijbrandts,
  6. P P Tak,
  7. K A Reedquist
  1. Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands

Statistics from Altmetric.com

Background

Angiogenesis contributes to inflammation and joint destruction in rheumatoid arthritis (RA). Angiopoietins 1 (Ang-1) and Ang-2, which mediate blood vessel remodelling, as well as their receptor Tie2, are expressed in inflamed synovial tissue. The authors have recently shown that Ang-1 expression relative to Ang-2 is significantly higher in RA compared to psoriatic arthritis, corresponding with enhanced activation …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.