Article Text
Genetics and gene regulation
Micro RNA analysis reveals novel genes in human systemic lupus erythematosus: miR-21 affects PDCD4 expression and regulates aberrant T cell responses
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Objective
MicroRNAs (miRNAs) are potent negative regulators of gene expression involved in innate and adaptive immune responses. The authors examined whether miRNAs are implicated in immune deregulation and lymphocyte hyperactivity in human systemic lupus erythematosus (SLE).
Methods
TaqMan miRNA arrays were used to study the expression of 365 miRNAs. …