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Bone/cartilage biology
Syndecan-4 regulates cartilage degradation in osteoarthritis
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  1. F Echtermeyer,
  2. J Betrand,
  3. I Meinecke,
  4. K Neugebauer,
  5. C Herzog,
  6. Y J Lee,
  7. Y W Song,
  8. R Dreier,
  9. T Pap
  1. Hannover Medical School, Hannover, Germany

https://doi.org/10.1136/ard.2010.129593u

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    Cartilage breakdown by loss of proteoglycans is one of the hallmarks of osteoarthritis (OA). The aggrecanase ADAMTS-5 has been shown to be responsible for proteoglycan loss in arthritic mouse cartilage. However, the mechanisms that lead to ADAMTS-5 activation during cartilage remodelling are poorly understood.

    Based on recent data that have implicated transmembrane heparan sulfate proteoglycans in matrix turnover, we analysed the relationship between syndecan-4 and ADAMTS-5 in osteoarthritic cartilage and in different animal models of OA. To study syndecan-4 …

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