Article Text
Bone/cartilage biology
Syndecan-4 regulates cartilage degradation in osteoarthritis
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Cartilage breakdown by loss of proteoglycans is one of the hallmarks of osteoarthritis (OA). The aggrecanase ADAMTS-5 has been shown to be responsible for proteoglycan loss in arthritic mouse cartilage. However, the mechanisms that lead to ADAMTS-5 activation during cartilage remodelling are poorly understood.
Based on recent data that have implicated transmembrane heparan sulfate proteoglycans in matrix turnover, we analysed the relationship between syndecan-4 and ADAMTS-5 in osteoarthritic cartilage and in different animal models of OA. To study syndecan-4 …