Article Text
Bone/cartilage biology
Immune complex-mediated inhibition of osteoclastogenesis: role for the inhibitory Fc γ receptor IIB in bone erosion in antigen-induced arthritis?
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Rheumatoid arthritis is characterised by osteoclast-mediated bone loss. In several studies it was shown that SHIP-/- mice are severely osteoporotic due to increased numbers of hyperreactive osteoclasts. Because SHIP is part of the signalling pathway of the inhibitory FcγRIIB, the aim of this study was to investigate the role of FcγRIIB in osteoclastogenesis and osteoclast function.
Compared with wild-type mice, bone erosion and cathepsin K staining were clearly enhanced during antigen-induced arthritis in the knee …