Article Text

Download PDFPDF

Natural autoantibodies reactive to glycosaminoglycans are disease state markers in rheumatoid arthritis and are associated with HLA
  1. B György,
  2. L Tóthfalusi,
  3. G Nagy,
  4. M Pásztói,
  5. P Géher,
  6. A Polgár,
  7. B Rojkovich,
  8. I Ujfalussy,
  9. P Misják,
  10. A Koncz,
  11. E Pozsonyi,
  12. G Füst,
  13. A Falus,
  14. E I Buzás
  1. Semmelweis University, Hungary

Statistics from


Although natural autoantibodies make up the majority of circulating immunoglobulins, they have received little attention lately. This study examined systematic antibodies (Abs) reactive to glycosaminoglycans (GAGs), the carbohydrate components of proteoglycans that are released in large amounts from degrading cartilage.


To measure Abs reactive to six different types of GAGs, a specialised ELISA was used in which the carbohydrates were covalently linked to the plastic surface through a 2 nm spacer. Sera from rheumatoid arthritis patients (n=6), …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.