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The relationship between the type I interferon signature and the response to rituximab in rheumatoid arthritis
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  1. R M Thurlings,
  2. M Boumans,
  3. J Tekstra,
  4. K Vos,
  5. D M van Westing,
  6. L G van Baarsen,
  7. C Bos,
  8. K A Kirou,
  9. D M Gerlag,
  10. M K Crow,
  11. C L Verweij,
  12. P P Tak
  1. Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, The Netherlands

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Objectives

To analyse the relationship between the type I interferon (IFN) signature and the response to rituximab in rheumatoid arthritis (RA) patients.

Methods

Twenty RA patients were treated with rituximab (cohort 1). As a read out for clinical response the decrease in disease activity score (DAS28) between week 0 and 24 was used. In peripheral blood mononuclear cells from baseline the presence of an IFN signature was analysed by measuring the expression levels of three IFN response genes …

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