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To analyse the relationship between the type I interferon (IFN) signature and the response to rituximab in rheumatoid arthritis (RA) patients.
Twenty RA patients were treated with rituximab (cohort 1). As a read out for clinical response the decrease in disease activity score (DAS28) between week 0 and 24 was used. In peripheral blood mononuclear cells from baseline the presence of an IFN signature was analysed by measuring the expression levels of three IFN response genes …
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