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B cells
Elevated levels of CD5+ B cells in spondyloarthritis patients
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  1. T Cantaert,
  2. Y Tiersma,
  3. C A Ambarus,
  4. J E Paramarta,
  5. P P Tak,
  6. L E De Rycke,
  7. D L Baeten
  1. Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands

https://doi.org/10.1136/ard.2010.129585g

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    Background

    We recently proposed that spondyloarthritis (SpA) is characterised by primary alterations in the innate rather than the acquired immune system. However, SpA patients develop a strong IgM antinuclear antibody profile upon tumour necrosis factor blockade. The characteristics of these autoantibodies are compatible with natural antibodies originating from ‘innate’ B cells rather than with genuine, pathogenic autoantibodies. As in mice natural autoantibodies are produced by CD5 expressing peritoneal B cells responding to innate immune signals, we aimed to quantify and …

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