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Tumour necrosis factor α (TNFα) blockade in spondyloarthritis (SpA) induces antibodies specific for double stranded DNA, which is a T cell independent (TI) antigen. As these antibodies were restricted to the IgM isotype and no antibodies to T cell dependent (TD) antigens were induced, we investigated here if TNF blockade impairs the induction and maturation of TD humoural responses.
30 SpA patients (20 treated …
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