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TNFα blockade impairs T cell dependent humoural responses
  1. G F Salinas,
  2. L De Rycke,
  3. T Cantaert,
  4. M van de Burg,
  5. B Barendregt,
  6. P Remans,
  7. P Peter Tak,
  8. D Baeten
  1. Clinical Immunology and Rheumatology, Academical Medical Centrum/Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands

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Objective

Tumour necrosis factor α (TNFα) blockade in spondyloarthritis (SpA) induces antibodies specific for double stranded DNA, which is a T cell independent (TI) antigen. As these antibodies were restricted to the IgM isotype and no antibodies to T cell dependent (TD) antigens were induced, we investigated here if TNF blockade impairs the induction and maturation of TD humoural responses.

Methods

30 SpA patients (20 treated …

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