Statistics from Altmetric.com
Takayasu's arteritis (TA) is a large vessel vasculitis of unknown origin involving the aorta and its major branches. T cell mediated autoimmunity is thought to play a major role in its pathogenesis. Based on findings in one patient with highly active disease we analysed for the first time the B cell compartment of patients with TA and could show that marked expansion of plasma cells can be found that correlates with disease activity and therefore qualifies as a novel biomarker. In addition treatment with the B cell depleting agent Rituximab proved to be successful in refractory patients. Therefore the role of B cells in TA needs to be reconsidered.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.