Anti-tumour necrosis factor (anti-TNF) therapy of patients with rheumatoid arthritis dates back to 1992, when the first proof-of-principle trials were performed in London by Maini and Feldmann. Considerable studies of the mechanism of action were performed, and insights into the way in which anti-TNF therapy delivers its benefit were obtained. In this brief review, certain aspects of knowledge acquired and the many gaps will be reviewed. Focus will be on the TNF-dependent cytokine cascade and what it means, and potential new approaches to treatment. Finally, an entertaining challenge: might many or even all unmet clinical needs be dealt with through cytokine analysis?
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Funding Support from Arthritis Research Campaign, Kennedy Institute of Rheumatology Trustees, Trillium Therapeutics Inc, Nuon Therapeutics Inc, which is gratefully acknowledged.
Competing interests MF is a consultant and shareholder for Nuon (Tranilast) and consultant to Trillium (CD200Fc).
Provenance and Peer review Not commissioned; externally peer reviewed.