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Circulating levels of frizzled-related protein (FRZB) are increased in patients with early rheumatoid arthritis and decrease in response to disease-modifying antirheumatic drugs
  1. Federica Corallini1,
  2. Paola Secchiero1,
  3. Gabriella Castellino2,
  4. Maurizio Montecucco3,
  5. Francesco Trotta2,
  6. Giorgio Zauli1,4
  1. 1Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
  2. 2Rheumatology Section, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
  3. 3Department of Rheumatology, IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy
  4. 4IRCCS, Burlo Garofolo Hospital, Trieste, Italy
  1. Correspondence to Professor Giorgio Zauli, Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy; giorgio.zauli{at}

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Products of the secreted frizzled-related protein (FRZB) families have crucial roles in the development and maintenance of bone, cartilage and joints, mainly by inhibiting the wnt and/β catenin pathway.1 In particular, while several important studies have associated FRZB (also known as sFRP3) with an increased susceptibility to the development of osteoarthritis,2,,4 no information is available on the potential role of circulating FRZB in early rheumatoid arthritis (ERA).

We have measured the serum levels of FRZB by ELISA (R&D Systems, Minneapolis, Minnesota, USA) in a cohort of patients presenting with ERA, defined as previously described.5 Serological signs of inflammation (raised erythrocyte sedimentation rate or C reactive …

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  • Ethics approval This study was conducted with the approval of the ethics commitee of the Universities of Pavia and Ferrara and written consent for all procedures was obtained from all subjects in accordance with the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Competing interests None.