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Products of the secreted frizzled-related protein (FRZB) families have crucial roles in the development and maintenance of bone, cartilage and joints, mainly by inhibiting the wnt and/β catenin pathway.1 In particular, while several important studies have associated FRZB (also known as sFRP3) with an increased susceptibility to the development of osteoarthritis,2,–,4 no information is available on the potential role of circulating FRZB in early rheumatoid arthritis (ERA).
We have measured the serum levels of FRZB by ELISA (R&D Systems, Minneapolis, Minnesota, USA) in a cohort of patients presenting with ERA, defined as previously described.5 Serological signs of inflammation (raised erythrocyte sedimentation rate or C reactive …
Footnotes
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Ethics approval This study was conducted with the approval of the ethics commitee of the Universities of Pavia and Ferrara and written consent for all procedures was obtained from all subjects in accordance with the Declaration of Helsinki.
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Provenance and peer review Not commissioned; externally peer reviewed.
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Competing interests None.