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Scientific interest in adipose tissue-derived peptides has increased dramatically in recent years.1 Several mediators known as adipo(cyto)kines were first associated with the pathophysiology of obesity-related complications; however, a significant role for adipokines such as leptin, adiponectin, resistin and visfatin in regulating immune responses and inflammation has recently been discovered.1 2 Several reports3,–,6 have already demonstrated association of these adipokines with the severity of rheumatoid arthritis (RA).
Vaspin, a member of the serine protease inhibitor family, and omentin (also known as intelectin) were recently identified in adipose tissue.7 8 Vaspin is an adipokine with insulin-sensitising effects that has been suggested to be a compensatory mediator for abrogating obesity and its inflammatory complications.7 Expression of the omentin gene was demonstrated in omental adipose tissue of patients …
Patient consent Obtained.
Competing Interests None.
Ethics approval This study was conducted with the approval of the local ethics committee and all patients gave informed consent.
Provenance and peer review Not commissioned; externally peer reviewed.