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Imaging evidence for persistent subclinical fasciitis and arthritis in tumour necrosis factor receptor-associated periodic syndrome (TRAPS) between febrile attacks
  1. N Quillinan1,
  2. A Mohammad1,
  3. G Mannion1,
  4. D O’Keeffe1,
  5. D Bergin1,
  6. R Coughlan1,
  7. M F McDermott2,
  8. D McGonagle2
  1. 1Department of Rheumatology, Merlin Park Hospital (Galway University Hospital), Renmore, Galway, Ireland
  2. 2NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, St James's University Hospital, University of Leeds, Leeds, UK
  1. Correspondence to Dr N Quillinan, Department of Rheumatology, Royal Free Hospital, Pond Street, London NW3 2QG, UK; niamhq{at}

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Tumour necrosis factor receptor-associated periodic syndrome (TRAPS),1 formerly known as familial Hibernian fever,2 3 is an archetypal hereditary periodic fever syndrome and is an autosomal dominant condition characterised by mutations in the TNFRSF1A gene.4 5 Periodicity of fevers is typical of TRAPS, with peritonitis, arthritis and fasciitis. It is also well recognised that some patients continue to feel unwell between attacks. That subclinical TRAPS is still ongoing in such circumstances is supported by persistent acute phase response.6 7 There are no specific features to localise a site for this persistent inflammatory response and, to date, no studies have been done to investigate this interesting observation.

Whole body MRI has recently been introduced for the assessment of various skeletal pathologies including malignancy, myositis and arthritis.8,,12 MRI …

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  • Patient consent Obtained.

  • Competing Interests None.

  • Ethics approval This study was conducted with the approval of the Galway University Hospitals research ethics committee.

  • Provenance and peer review Not commissioned; externally reviewed.