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Comorbidity profiles among patients with ankylosing spondylitis: a nationwide population-based study
  1. Jiunn-Horng Kang1,
  2. Yi-Hua Chen2,
  3. Herng-Ching Lin3
  1. 1Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan
  2. 2School of Public Health, Taipei Medical University, Taipei, Taiwan
  3. 3School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
  1. Correspondence to Professor Herng-Ching Lin, School of Health Care Administration, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan; henry11111{at}


Objective Ankylosing spondylitis (AS) is a systemic inflammatory disease that can result in chronic pain and disability. This study aimed to analyse the prevalence and risk of medical comorbidities in patients with AS compared with the general population.

Methods 11 701 patients with AS and 58 505 matching controls were selected for analysis from the National Health Insurance Research Dataset (NHIRD) in Taiwan. The Elixhauser comorbidity index was used for selecting medical comorbidities. Pearson χ2 tests and conditional logistic regression a nalyses were performed to examine the prevalence and risk of comorbidities between these two groups.

Results Patients with AS were at increased risk for multiple systemic comorbidities including cardiovascular, neurological, pulmonary, gastrointestinal, endocrine, haematological and mental illness. The most prevalent comorbidities in patients with AS were hypertension (16.4%), peptic ulcers (13.9%) and headaches (10.2%).

Conclusion The results show that patients with AS have a higher prevalence of multiple comorbidities than the general population in Taiwan. These findings are consistent with previous studies done in Western populations. The results could be useful for both the clinical management of patients with AS and for researching the underlying pathological mechanisms.

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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