Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study

S M M Verstappen; M F Bakker; A H M Heurkens; M J van der Veen; A A Kruize; M A W Geurts; J W J Bijlsma; J W G Jacobs

doi:10.1136/ard.2008.106617

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Clinical and epidemiological research

Extended report

Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study

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	Abstract	Full	Pdf
Jul 2009	279	0	140
Aug 2009	52	0	42
Sep 2009	20	0	30
Oct 2009	14	0	16
Nov 2009	7	0	15
Dec 2009	15	0	13
Jan 2010	40	0	15
Feb 2010	19	0	12
Mar 2010	36	0	19
Apr 2010	9	0	3
May 2010	71	14	74
Jun 2010	77	19	108
Jul 2010	22	28	62
Aug 2010	44	12	30
Sep 2010	52	13	27
Oct 2010	24	16	31
Nov 2010	16	17	22
Dec 2010	14	12	22
Jan 2011	15	9	14
Feb 2011	16	8	25
Mar 2011	21	9	25
Apr 2011	21	11	13
May 2011	19	9	12
Jun 2011	23	11	15
Jul 2011	52	13	18
Aug 2011	22	8	11
Sep 2011	17	6	11
Oct 2011	30	5	10
Nov 2011	37	11	15
Dec 2011	38	4	11
Jan 2012	60	12	10
Feb 2012	41	4	5
Mar 2012	40	3	7
Apr 2012	62	5	10
May 2012	36	10	14
Jun 2012	38	3	5
Jul 2012	48	8	12
Aug 2012	35	6	9
Sep 2012	45	4	9
Oct 2012	53	6	9
Nov 2012	47	6	9
Dec 2012	40	4	8
Jan 2013	55	5	7
Feb 2013	37	5	5
Mar 2013	67	4	15
Apr 2013	59	2	9
May 2013	39	3	4
Jun 2013	26	5	4
Jul 2013	29	3	5
Aug 2013	32	7	6
Sep 2013	23	5	2
Oct 2013	29	7	10
Nov 2013	31	4	8
Dec 2013	21	3	5
Jan 2014	28	2	6
Feb 2014	19	7	9
Mar 2014	24	5	7
Apr 2014	33	4	4
May 2014	57	3	4
Jun 2014	7	1	3
Jul 2014	43	13	11
Aug 2014	26	4	2
Sep 2014	21	10	8
Oct 2014	28	8	11
Nov 2014	19	0	1
Dec 2014	24	1	4
Jan 2015	28	5	4
Feb 2015	20	1	3
Mar 2015	33	8	11
Apr 2015	30	2	2
May 2015	17	4	7
Jun 2015	22	2	10
Jul 2015	12	5	4
Aug 2015	32	5	7
Sep 2015	26	4	6
Oct 2015	7	3	4
Nov 2015	11	3	5
Dec 2015	26	8	8
Jan 2016	21	4	4
Feb 2016	20	7	12
Mar 2016	22	4	11
Apr 2016	22	1	5
May 2016	16	3	3
Jun 2016	25	3	5
Jul 2016	33	1	2
Aug 2016	25	6	6
Sep 2016	46	5	8
Oct 2016	32	2	2
Nov 2016	36	4	3
Dec 2016	20	9	7
Jan 2017	26	0	4
Feb 2017	26	3	6
Mar 2017	32	6	7
Apr 2017	39	4	5
May 2017	38	8	9
Jun 2017	45	8	11
Jul 2017	61	0	17
Aug 2017	76	4	8
Sep 2017	102	8	12
Oct 2017	84	8	5
Nov 2017	58	11	9
Dec 2017	66	5	6
Jan 2018	101	9	9
Feb 2018	116	5	6
Mar 2018	55	7	2
Apr 2018	57	6	5
May 2018	75	1	1
Jun 2018	65	6	4
Jul 2018	90	2	1
Aug 2018	54	2	5
Sep 2018	25	1	1
Oct 2018	202	4	3
Nov 2018	60	8	2
Dec 2018	40	4	3
Jan 2019	52	14	8
Feb 2019	34	2	2
Mar 2019	45	7	4
Apr 2019	57	4	2
May 2019	70	1	1
Jun 2019	44	1	1
Jul 2019	54	7	2
Aug 2019	37	4	0
Sep 2019	32	1	1
Oct 2019	49	9	2
Nov 2019	23	1	0
Dec 2019	32	0	0
Jan 2020	87	6	3
Feb 2020	39	4	1
Mar 2020	109	1	0
Apr 2020	21	1	1
May 2020	44	2	1
Jun 2020	54	3	3
Jul 2020	49	15	4
Aug 2020	45	5	2
Sep 2020	54	4	3
Oct 2020	58	7	6
Nov 2020	46	7	6
Dec 2020	34	1	4
Jan 2021	56	4	3
Feb 2021	36	4	2
Mar 2021	37	3	3
Apr 2021	26	4	3
May 2021	35	4	7
Jun 2021	0	0	1
Jul 2021	1	1	3
Aug 2021	2	2	3
Sep 2021	6	3	3
Oct 2021	59	9	4
Nov 2021	81	3	1
Dec 2021	59	6	6
Jan 2022	67	0	0
Feb 2022	63	1	0
Mar 2022	113	4	2
Apr 2022	45	1	0
May 2022	105	3	1
Jun 2022	121	4	0
Jul 2022	73	5	3
Aug 2022	82	3	1
Sep 2022	74	9	0
Oct 2022	113	10	0
Nov 2022	66	3	1
Dec 2022	65	4	1
Jan 2023	95	3	1
Feb 2023	115	3	1
Mar 2023	34	1	0
Apr 2023	4	0	0
May 2023	59	1	0
Jun 2023	20	1	1
Jul 2023	58	4	2
Aug 2023	21	3	2
Sep 2023	35	4	2
Oct 2023	107	4	0
Nov 2023	42	8	0
Dec 2023	69	0	0
Jan 2024	57	8	0
Feb 2024	100	8	0
Mar 2024	39	11	0
Total	8028	892	1512

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