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Association between GLUT9 and gout in Japanese men
  1. Wako Urano1,
  2. Atsuo Taniguchi1,
  3. Naohiko Anzai2,
  4. Eisuke Inoue1,
  5. Chieko Sekita1,
  6. Hitoshi Endou2,3,
  7. Naoyuki Kamatani1,
  8. Hisashi Yamanaka1
  1. 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
  2. 2Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
  3. 3J-Pharma Co, Ltd, Tokyo, Japan
  1. Correspondence to Dr Wako Urano, Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Sinjuku-ku, Tokyo 162-0054, Japan; wako{at}ior.twmu.ac.jp

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Recently, the association between single nucleotide polymorphisms (SNPs) in GLUT9 and the serum levels of uric acid (sUA) or gout has been shown in Caucasians.1,,5 However, the associations have not been replicated in other ethnicities. Here, we report an association between GLUT9 and the development of gout in Japanese men.

We isolated genomic DNA from 181 Japanese male patients with gout6 and from 595 Japanese male controls.7 The genotypes of intronic SNPs in GLUT9 (rs1014290, rs6449213, rs7442295, rs6855911, rs737267), previously reported as associated with sUA or gout,1,,5 and non-synonymous SNPs (rs1680979, rs3733591, rs2280205) were determined using the TaqMan method (Applied Biosystems, Foster City, California, USA). Statistical analysis was made by χ2 test, …

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Footnotes

  • Funding This work was supported by health and labour sciences research grants for research on human genome tailor made, a grant for research for the future programme from the Japan Society for the Promotion of Science, and a grant from the Hisako Yamakawa Award at Tokyo Women's Medical University.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Tokyo Women's Medical University Hospital Ethics Committee for Human Genome Research.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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